Typically, you are supposed to do 3 treatments, a week in between each. So I'll probably do two more times. I'll check tomorrow to see if there are any issues. All I did was put skimmer back online. Most either do large water change and/or run carbon and put skimmer online after about 8 hours after dosing. But there are some that said they didn't do any of that without any issues. If there aren't any issues, I won't do anything... maybe large water change after the 2nd or 3rd treatment, and then carbon at the end. I want to make sure all the red bugs and their offspring are gone for good. Some also have seen success with only one treatment. These are just my internet findings of both Interceptor tablets and Dr. G's SPS dip.