depends what your input is.
the carbon and sediment filters should be changed roughly every 6 months (depends upon usage), the RO membrane can last many many years, you should get roughly 95% less TDS on the output than input. So if you're getting 10ppm out, and you have roughly 200 ppm at the faucet I wouldn't worry at all. The DI resin should bring it down to 0ppm, so if it's less than 2ppm I wouldn't worry much at all.