I would certainly purge it. If you don’t, whatever is sitting in the tubing between the fridge and the tank is just sitting there at room temperature. If you’re dosing massive amounts of whatever and it’s only sitting at room temperature for a few hours, maybe not such a big deal. In my case the 1 or 2 mL of phyto I dose per day would take quite a while to actually make it to the tank because the fridge is located pretty far away. Maybe a day or two at room temperature, no bueno. But your scenario matters.