The bad news: my achilles hybrid started scratching again a week or so after the last round of prazipro. Argh.
The good news: after observing and watching for additional symptoms, I'm reasonably confident it's gill flukes due to the primary symptoms being scratching, rapid breathing in some of the tangs, and modest flashing, no white dots/etc, and the fact that prazipro stopped them scratching last time. I tried to confirm this by catching a fish or two for a freshwater bath, but only succeeded in stressing them out. So I took a sample and submitted it for an Aquabiomics test with the rationale that either 1) I'll have confirmation that there were flukes in the tank and I'm going down the right path, or 2) I don't have flukes and it'll give me a better idea of what's going on.
So, operating under the assumption that it's gill flukes - and the fact they seem to be more difficult to treat - I checked on Humble Fish for protocols from people that had used prazipro to treat gill flukes. After speaking to several people who had, I decided to take a heavier-handed approach and do 2.5 mg/ml of prazipro on day 1, 5, 7, and 9. Noting that I turned off carbon and UV to start, turned it on on Day 4, then turned them off prior to each dose for 24 hours before resuming. (Given the mechanism of action of praziquantel, 24 hours should be sufficient to work, it's fully out of the tank within ~72 hours without intervention, and the UV/carbon helps break it down and remove it to prevent overdosing).
My rationale is that my system doesn't have much inverts in it so it's okay to go heavier, and that the more frequent dosing should help overwhelm any treatment-resistant/difficult to treat flukes. Yesterday was the last dose, then I'll be doing a large water change tomorrow and hoping for the best.
The good news: after observing and watching for additional symptoms, I'm reasonably confident it's gill flukes due to the primary symptoms being scratching, rapid breathing in some of the tangs, and modest flashing, no white dots/etc, and the fact that prazipro stopped them scratching last time. I tried to confirm this by catching a fish or two for a freshwater bath, but only succeeded in stressing them out. So I took a sample and submitted it for an Aquabiomics test with the rationale that either 1) I'll have confirmation that there were flukes in the tank and I'm going down the right path, or 2) I don't have flukes and it'll give me a better idea of what's going on.
So, operating under the assumption that it's gill flukes - and the fact they seem to be more difficult to treat - I checked on Humble Fish for protocols from people that had used prazipro to treat gill flukes. After speaking to several people who had, I decided to take a heavier-handed approach and do 2.5 mg/ml of prazipro on day 1, 5, 7, and 9. Noting that I turned off carbon and UV to start, turned it on on Day 4, then turned them off prior to each dose for 24 hours before resuming. (Given the mechanism of action of praziquantel, 24 hours should be sufficient to work, it's fully out of the tank within ~72 hours without intervention, and the UV/carbon helps break it down and remove it to prevent overdosing).
My rationale is that my system doesn't have much inverts in it so it's okay to go heavier, and that the more frequent dosing should help overwhelm any treatment-resistant/difficult to treat flukes. Yesterday was the last dose, then I'll be doing a large water change tomorrow and hoping for the best.