It’s UV exposure- intensity level (watts) x seconds exposed (inverse of gph). So having them in series means twice the exposure, the equivalent of running half the flow rate (like Randy said). That said, having them in parallel is probably just about as good since on average you’ll be delivering the same increased intensity x exposure to whatever is in the water.
Killing stuff in this case isn’t black and white, it’s probability of killing really. Even the term killing isn’t really what we’re going for, more like enough DNA damage that it can’t replicate. There’s a lot of randomness involved making it more statistical, so really it just boils down to more is better, up to the point of practicality.
Some people who have 2 UV’s plumb them separately, one high flow for algae and bacteria, and the other low flow for parasites. Theoretically it makes sense, but again this isn’t as exact of a science as people want it to be.