Just run it overnight for 24 hours if you're not in a rush (which you shouldn't be since most tanks can do w/out a skimmer for that length of time, especially a new one). That should remove any sort of residual oils or residues. You can run it for less, but I prefer to run it in the solution for 24 hours. You also don't have to run it at the highest speed since with vinegar, your skimmer will go nuts and overflow. Just pull the cap off of it and let it do its own thing.